
Coronary artery disease (CAD) is a condition in which the arteries that supply blood to the heart itself become narrowed or blocked due to a buildup of plaque. This plaque is made of cholesterol, fat, and other substances that stick to the artery walls.
As the arteries narrow, less oxygen-rich blood reaches the heart muscle. This can cause chest pain, shortness of breath, or even a heart attack. CAD is the most common form of heart disease and
a major cause of death globally.
People worldwide live with CAD
Someone in the US has a heart attack
Of all hospitalizations in the US are due to CAD
Of heart attacks occur without prior warning
Of US deaths over age 35 are caused by CAD
Of cardiovascular-related deaths are linked to modifiable risk factors

Current diagnostic tools often detect CAD at advanced stages, missing opportunities for early intervention
90% of AMI patients have significant CAD
Only 50% of patients sent for coronary angiography require treatment
Black, Hispanic, and Native Americans experience disproportionately high rates of CAD

The average cardiac event costs $50,000 in immediate care
First-year medical costs after a heart attack range from $50,000 to $87,000 per patient
Lifetime treatment of heart attack patients in the US can reach $1 million
CAD imposes a major burden on the US healthcare system, with annual costs exceeding $220 billion
Chest pain is the most common complaint at US PCP clinics – around 3M annually
Only 15% of patients with chest pain have CAD
Neither PCPs nor cardiologists have a point-of-care exam to determine whether the patient has significant CAD

Due to its life-risking nature, nearly all chest pain patients are referred for further examination
Many are referred to a cardiologist – yet nearly 50% of counties in the US do not have one
The frontline exams – stress tests – are not accurate enough, this leads to:

Enables early and accurate detection
Closes gaps in preventive care and slows disease progression
Supports life changes that reduce morbidity and mortality